Dr. Baowei Fei’s research is highlighted by Emory Magazine: Double Vision – By Mary J. Loftus

“The combined system can provide opportunities for basic research and can open a new window to studying diseases such as Alzheimer’s, Parkinson’s, drug addiction, cancer, and cardiovascular disease,” says Assistant Professor of Radiology Baowei Fei, a Georgia Cancer Coalition Distinguished Scholar. Dr. Fei’s team is working to develop and improve imaging software for the hybrid system. – Autumn 2010

For more information, please visit: http://www.emory.edu/EMORY_MAGAZINE/2010/autumn/scanner.html

Dr. Baowei Fei’s work on MR/PET is highlighted as a featured innovation at the Office of Technology Transfer (OTT) at Emory University

Magnetic resonance imaging (MR) shows details about the soft tissues of the body, such as every curve and indentation in the brain, while positron emission tomography (PET) records processes, such as how much energy is being used or how much blood is flowing into a region. When these imaging techniques were combined in the same scanner a few years ago, a real challenge since the MRI’s strong magnetic field and the PET’s detector and electronics tend to interfere with each other scientists started thinking about the potential wealth of information that could be provided.

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When Two is Better Than One: Perfecting the Combined MR/PET

Dr. Baowei Fei received a Coulter Translational Research Award to develop quantification tools for combined MR/PET

PET (Positron Emission Tomography) provides insight into the metabolic and functional alterations related to pathologic process, and CT (Computed X-Ray Tomography) and MRI (Magnetic Resonance Imaging) reveal anatomical changes due to diseases. The combination of two imaging modalities significantly expands their utility, improving sensitivity and specificity for disease detection and diagnosis. With this grant from the Wallace H. Coulter Department of Biomedical Engineering at Georgia Tech and Emory University Dr. Fei and his team will develop image quantification tools that include image registration, classification, segmentation, and attenuation correction for potential use in combined MR/PET.

Dr. Baowei Fei received a Young Investigator Award from the Society of Nuclear Medicine (SNM)

At the 57th Annual Meeting of the Society of Nuclear Medicine (SNM) in Salt Lake City, Utah in June 2010, Dr. Baowei Fei received the Young Investigator Award for his research on Image Quantification and Attenuation Correction for Combined MRI/PET from the SNM. Dr. Fei received the 1st place award from the SNM Computer and Instrumentation Council. He and his co-colleagues have developed tools for image registration, classification, segmentation and attenuation correction for the potential use in combined MRI/PET. Other colleagues who contributed to this work include Mr. X. Yang, Dr. J. Nye, Ms. M. Jones, Dr. J. Aarsvold, Ms. N. Raghunath, Dr. C. Meltzer and Dr. J. Votaw.

Dr. Baowei Fei’s work on photodynamic therapy and nanoparticle-based drug delivery was highlighted by Nature Materials

Photodynamic therapy (PDT) is a promising method for treating several cancers that uses photosensitizers. The photosensitizer accumulates in target tissue and is excited using light, generating reactive oxygen species that induce cell death. To enter the target area PDT drugs need to be lipophilic, however this presents problems: lack of solubility in the physiological conditions experienced en route to the target means that they usually take at least 24 hours to get to the tumour. Baowei Fei, Clemens Burda and co-workers have synthesized a PDT drug complex that significantly decreases the delivery time and enables quantitative monitoring of the process. Polyethylene glycol (PEG; a compound approved for human intravenous applications) is attached to gold nanoparticles functionalized with the PDT drug, silicon phthalocyanine-4. Chains of PEG wrap around the drug allowing the system to disperse in aqueous conditions. Free silicon phthalocyanine-4 takes 1-2 days to accumulate in a tumour site; using the new complex this is reduced to less than two hours in vivo in cancer-bearing mice with the tumour reducing in size within one week of treatment.

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Dr. Baowei Fei received a Pilot grant from the NIH-funded Emory Molecular and Translational Imaging Center

We envision that molecular imaging can detect cancer at the cellular level, can monitor drug distribution in vivo, can guide therapy to the target, and can evaluate efficacy immediately after therapy. Dr. Fei and his team will develop and evaluate multimodality imaging methods (fluorescence imaging, PET and MR imaging) for early detection of therapeutic response in pre-clinical cancer models.

Dr. Baowei Fei was selected as a Georgia Cancer Coalition Distinguished Cancer Scholar

The Georgia Cancer Coalition established the Distinguished Cancer Clinicians and Scientists program as the cornerstone of its research agenda. The goal of the program is to recruit to Georgia leading and nationally renowned cancer clinicians and scientists who are engaged in the most promising areas of cancer research. The selection of the scholars is closely aligned with the National Cancer Institute’s “Extraordinary Opportunities in Cancer Research,” which has identified areas of discovery that hold promise for making significant progress against all cancers. This competitive and prestigious award carries with it a five-year grant payable to Emory University to support Dr. Fei’s research on cancer imaging. – June 15, 2009

For more information about Georgia Cancer Coalition, please visit: http://www.georgiacancer.org

Dr. Baowei Fei received a URC grant to fund his research project entitled “Motion Correction and Quantitative Image Analysis for Kidney MR Imaging.”

The project is supported by the NIH sponsored Atlanta Clinical and Translational Institute (A-CTSI). (Co-Pls:Baowei Fei and Diego Martin. Co-investigator: John Votaw)

For more information about the Atlanta Clinical and Translational Institute, please visit: http://www.atlantactsi.org

For more information about the University Research Committee (URC), please visit: http://www.urc.emory.edu