@article{Taleghani01052012,
author = {Taleghani, Pooneh and Amzat, Rianot and Osunkoya, A. and Savir-Baruch, Bital and Nieh, Peter and Master, Viraj and Fei, Baowei and Fox, Timothy and Goodman, Mark and Schuster, David}, 
title = {Synthetic amino acid PET in primary prostate carcinoma: Correlation of pre-surgical imaging with radical prostatectomy specimens},
volume = {53}, 
number = {supplement 1}, 
pages = {117}, 
year = {2012}, 
abstract ={
        117
      
          Objectives
        anti-3-[18F] FACBC is a synthetic amino acid positron emission tomography (PET) radiotracer with utility in the detection of recurrent prostate carcinoma (Radiology 2011;259:852). The aim of this study is to correlate uptake of anti-3-[18F] FACBC with histology of prostatectomy specimens in primary prostate carcinoma.
          Methods
        10 patients with prostate carcinoma pre-radical prostatectomy underwent 45 minute dynamic PET-CT of the pelvis after IV injection of 347.8 ± 81.4 MBq anti-3-[18F] FACBC, then registered to separately acquired prostate MR. Each prostate was divided into 12 sextants (left/right; apex, mid, base; anterior/posterior) and analyzed visually for abnormal focal uptake at 4, 16, 28 and 40 min by a single reader blinded to pathology. SUVmax and total lesion activity (TLA) of each sextant was calculated. Histology and Gleason scores were similarly recorded by a urologic pathologist blinded to imaging. Imaging and histologic analysis were then compared.
          Results
        79 sextants had malignancy and 41 were benign. Highest combined sensitivity and specificity was at 28 min by visual analysis; 81.25% and 50% respectively. Examination of quantitative lesion/background or lesion/marrow values did not improve upon visual criteria. At 28 min mean (±SD) SUVmax of malignant versus benign sextants was 4.0±1.3 vs 3.4±0.9 (p<0.05). TLA (suv*ml) at 28 min was 2.9±1.7 for malignant vs 2.2±1.0 (p<0.05) for benign sextants. SUVmax positively correlated with Gleason score (p<0.05).
          Conclusions
        Visual analysis of anti-3-[18F] FACBC PET of primary prostate carcinoma provided highest combined diagnostic performance at 28 min. Though there was a significant difference between SUVmax and TLA of benign vs malignant sextants, considerable overlap was present. SUVmax positively correlated with increasing Gleason scores.
          Research Support
        NIH (1 P50 CA128301-01A1) and the Georgia Cancer Coalition}, 
URL = {http://jnm.snmjournals.org/content/53/supplement_1/117.abstract}, 
journal = {Journal of Nuclear Medicine} 
}