Preclinical Imaging

The multipurpose research system is a high-resolution magnetic resonance spectroscopy and imaging scanner for 2- or 3-dimensional image reconstruction based on the principles of nuclear magnetic resonance. The high-field system is equipped with multiple gradient sets specifically for high-resolution in-vivo imaging applications (< 100um). The Biospec® system is also equipped with broadband capabilities for multinuclear imaging and spectroscopy applications (ex. 1H, 31P, 15N, 13C, 19F). The system is also capable of cardiac / respiratory gating / monitoring to limit the negative effects of motion on image quality. This feature is critical for imaging animals with high respiration / heart rates. This system is located at the Division of Animal Division (DAR) in the Whitehead Building at Emory University.

MRI_T2_Result

T2-weighted MR images of a tumor-bearing mouse before photodynamic therapy (PDT) and 24-hr after PDT (right). The signal intensity values changed 24-hr after the treatment. Compared to the T2 map pre-PDT (bottom), the T2 values increased 24-hr after the treatment, especially within the treated tumor (arrow).

Selected Publications

Yogananda CG, Shah BR, Nalawade S, Murugesan GK, Frank FY, Pinho MC, Wagner BC, Mickey B, Patel TR, Fei BW, Madhuranthakam AJ, Maldjian JA. MRI-based deep learning method for determining methylation status of the 06 methylguanne DNA methyltransferase promoter outperforms tissue based methods in brain gliomas. bioRxiv 2020.

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Zhou X, Ma L, Halicek M, Dormer J, Fei BW (Corresponding author). Development of a new polarized hyperspectral imaging microscope. Imaging, Therapeutics, and Advanced Technology in Head and Neck Surgery and Otolaryngology 2020; 11213(1121308). International Society for Optics and Photonics,
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Zhou X, Dormer JD, Fei BW. Development of a polarized hyperspectral microscope for cardiac fiber orientation imaging. Diagnostic and Therapeutic Applications of Light in Cardiology 2020; 11215(112150V). International Society for Optics and Photonics,
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Ma L, Liu X, Fei BW. A multi-level similarity measure for the retrieval of the common CT imaging signs of lung diseases. Medical & Biological Engineering & Computing; 2020:1-15.
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Mavuduru A, Halicek M, Shahedi M, Little JV, Chen AY, Myers LL, Fei BW (Corresponding author). Using a 22-layer U-Net to perform segmentation of squamous cell carcinoma on digitized head and neck histological images. Medical Imaging 2020: Digital Pathology; 11320(113200C). International Society for Optics and Photonics,

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Vargas J, Le P, Shahedi M, Gahan J, Johnson B, Dormer JD, Shahub S, Pfefferle M, Judson BO, Alshara Y, Li Q. A complex dual-modality kidney phantom for renal biopsy studies. Medical Imaging 2020: Ultrasonic Imaging and Tomography; 11319(113190J). International Society for Optics and Photonics,

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Mahajan A, Dormer J, Li Q, Chen D, Zhang Z, Fei BW (Corresponding author). Siamese neural networks for the classification of high-dimensional radiomic features. Medical Imaging 2020: Computer-Aided Diagnosis; 11314(113143Q). International Society for Optics and Photonics,

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Bettati P, Chalian M, Huang J, Dormer J, Shahedi M, Fei BW (Corresponding author). Augmented reality-assisted biopsy of soft tissue lesions. Medical Imaging 2020: Image-Guided Procedures, Robotic Interventions, and Modeling; 11315(113150W). International Society for Optics and Photonics,

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Halicek M, Ortega S, Fabelo H, Lopez C, Lejeune M, Callico GM, Fei BW (Corresponding author). Conditional generative adversarial network for synthesizing hyperspectral images of breast cancer cells from digitized histology. Medical Imaging 2020: Digital Pathology; 11320(113200U). International Society for Optics and Photonics,

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Abiodun-Ojo OA, Akintayo AA, Akin-Akintayo O, Tade FI, Nieh PT, Master VA, Alemozaffar M, Osunkoya AO, Goodman MM, Fei BW (Corresponding author). 18F-Fluciclovine parameters on targeted prostate biopsy associated with true positivity in recurrent prostate cancer. Journal of Nuclear Medicine; 60(11): 1531-1536.

Nalawade S, Murugesan GK, Vejdani-Jahromi M, Fisicaro RA, Yogananda GCB, Wagner B, Mickey B, Maher E, Pinho MC, Fei BW, Madhuranthakam AJ, Maldjian JA. Classification of brain tumor isocitrate dehydrogenase status using MRI and deep learning. Journal of Medical Imaging; 6(4): 046003.

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Fei BW. Hyperspectral imaging for cancer detection and image-guided surgery. SPIE Photonics West – Design and Quality for Biomedical Technologies XII.

Mei K, Hu B, Fei BW, Qin B. Phase asymmetry ultrasound despeckling with fractional anisotropic diffusion and total variation. IEEE Transactions on Image Processing (2019); 29: 2845-2859.

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Halicek M, Shahedi M, Wang X, Little JV, Patel M, Griffith CC, El-Diery MW, Chen AY, Fei BW (Corresponding author). Automated detection of squamous cell carcinoma from head and neck cancer patients in digitized whole-slide histological images using deep learning. The Annual Meeting of the Biomedical Engineering Society.

Lu G, Wang DS, Qin X, Muller S, Wang X, Chen AY, Chen ZG, Fei BW (Corresponding author). Detection and delineation of squamous neoplasia with hyperspectral imaging in a mouse model of tongue carcinogenesis. Journal of Biophotonics;11(3):e201700078.

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Ma L, Lu G, Wang D, Wang X, Chen ZG, Fei BW. Deep learning-based classification for head and neck cancer detection with hyperspectral imaging in an animal model, Proc. SPIE 10137, Medical Imaging 2017: Biomedical Applications in Molecular, Structural, and Functional Imaging, 101372G, March 13, 2017, Orlando, FL.

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Dormer JD, Meng Y, Zhang X, Jiang R, Wagner MB, Fei BW, Estimating cardiac fiber orientations in pig hearts using registered ultrasound and MR image volumes, Proc. SPIE 10139, Medical Imaging 2017: Ultrasonic Imaging and Tomography, 101391G, March 15, 2017, Orlando, FL.

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Fei BW, Lu G, Halicek M, Wang X, Zhang HZ, Little JV, Magliocca K, Patel MR, Griffith CC, El-Diery MW. Label-free hyperspectral imaging and quantification methods for surgical margin assessment of tissue specimens of cancer patients. 2017 39th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC):4041-4045.

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Lu G, Qin X, Wang D, Muller S, Zhang H, Chen A, Chen ZG, Fei BW (Corresponding author). Hyperspectral imaging of neoplastic progression in a mouse model of oral carcinogenesis. Proceedings of SPIE – The International Society for Optical Engineering 2016; 9788:978812. PubMed PMID:27656034.

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Lu G, Qin X, Wang D, Muller S, Zhang H, Chen A, Chen ZG, Fei BW (Corresponding author). Quantitative diagnosis of tongue cancer from histological images in an animal model. Proceedings of SPIE – The International Society for Optical Engineering 2016; 9791: 97910L. PubMed PMID:27656036.

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Qin X, Wang S, Shen M, Zhang X, Lerakis S, Wagner MB, Fei BW (Corresponding author). 3D in vivo imaging of rat hearts by high frequency ultrasound and its application in myofiber orientation wrapping. Proceedings of SPIE – The International Society for Optical Engineering 2015; 9419:941906. PubMed PMID:26412926.

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Qin X, Wang S, Shen M, Zhang X, Lerakis S, Wagner MB, Fei BW (Corresponding author). Register cardiac fiber orientations from 3D DTI volume to 2D ultrasound image of rat hearts. Proceedings of SPIE – The International Society for Optical Engineering 2015; 9415:94152M. PubMed PMID:26855466.

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Lu G, Halig L, Wang D, Chen ZG, Fei BW (Corresponding author). Hyperspectral imaging for cancer surgical margin delineation: registration of hyperspectral and histological images. Proceedings of SPIE – The International Society for Optical Engineering 2014; 9036:90360S. PubMed PMID:25328640.

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Fei BW, Lu G, Pike R, Wang D, GZ Chen, Medical Hyperspectral Imaging for the Detection of Head and Neck Cancer in Animal Models, The Annual Meeting of the American Association of Physics in Medicine (AAPM), Austin, TX, July 20-24, 2014.

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Fei BW (Corresponding author), Wang H, Meyers JD, Feyes DK, Oleinick NL, Duerk JL. High-field magnetic resonance imaging of the response of human prostate cancer to Pc 4-based photodynamic therapy in an animal model. Lasers in Surgery and Medicine 2007; 39:723-730.

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Fei BW, Wang H, Muzic RF, Flask CA, Feyes DK, Wilson DL, Duerk JL, Oleinick NL. Finite element model-based tumor registration of microPET and high-resolution MR images for photodynamic therapy in mice. SPIE Medical Imaging: Physiology, Function, and Structure from Medical Images, Edited by Amir A. Amini, Armando Manduca, Proceeding of SPIE 2006;6143:61433I-1~10.

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